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KMID : 0378119820090020273
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Chungnam Medical Journal
1982 Volume.9 No. 2 p.273 ~ p.284
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The Effect of Experimental Ocular Hypertension on the Ultrastructure of the Optic Nerve
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Abstract
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The purpose of this study was to investigate the mechanism of the optic nerve damage in glaucoma. Rabbits, which are lack of lamina cribrosa, were used as the experimental material because the observation of the ultrastructural change of the rabbit optic nerve following experimental ocular hypertension will give meaningful evidance in supporting
the mechanical compression theory by lamina cribrosa on the optic nerve axon.
High intraocular pressure was induced by elevating the height of the saline bottle, which
was connected to rabbit eyeball and manometer through the infusion needle and 3 way stop-cock.
Rabbits were divided into 4 groups according to the level of ´intraocular pressure and
the eyeball was enucleated 12 hours after elevation of intraocular pressure for electron microscopic study.
The electron microscopic study of the optic nerve revealed no ultrastructural change in 40 and 60 mmHg groups and occasionally mild axonal degeneration in 80 and 100 mmHg groups. The following conclusions were obtained;
1. The optic nerve damage in glaucoma seems to be due to the mechanical compression on the optic nerve axon by lamina cribrosa.
2. The optic nerve damage is partially due to the ischemia when the level of intraocular pressure is same or above the mean retinal arterial pressure.
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